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发表于 2013-9-2 14:23:01
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本帖最后由 feynord 于 2013-9-3 13:28 编辑
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Message 74738 - Posted 15 Dec 2012 14:31:41 UTC | The CASP10 meeting just finished and all the results are on line so you can see what all your contributions made possible! Ray has posted a great summary of the results in the CASP10 thread on the science message boards. Overall, Rosetta@home was top or near top in most categories. I hate to embarrass David Kim who created RosettaHome and has kept it going, but his contact guided predictions were the highlight of CASP10 as they were vastly better than those of any other group. You can see this at
http://predictioncenter.org/casp ... =others&groups_id=4
David's predictions are the black lines, those of other groups are in orange, better models stay below the rest of the pack.
Thanks to all of you who contributed to CASP10!!
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2012年12月15日CASP10大赛顺利落幕,所有的结果都在网上公布了,大家可以去看自己的贡献了!参见Ray的总结帖。Rosetta@home在几乎所有的项目中都表现优异。在此我要感谢David Kim,他创立并维护着Rosetta@home,在CASP10中预测之准确超过其他所有的研究组。参见这个网页,David的预测是(每个蛋白质右侧小图中的)黑线,其他研究组的结果是桔黄色线,线越低越好哦。
感谢志愿者们为CASP10做出贡献!
Message 75215 - Posted 11 Mar 2013 1:31:45 UTC | We have learned to design a new class of proteins which could be useful both as drugs and in sensors. As I've explained before, most drugs are small molecules with fewer than 50 atoms. There are many drugs, such as blood thinning agents, which are very dangerous if given in too large doses. We have succeeded in designing proteins which bind to specific small molecules very tightly. These proteins could be used as antidotes in case of overdose with the target small molecule-for example we've designed a protein which could be useful to treat toxicity due to overdose of the drug digoxin used to treat heart disease. With collaborators, we are working to use these designed proteins to detect levels of the target small molecules in the blood or in the environment.
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2013年3月11日
我们学会了该如何去设计一类既可能当药物也可能用于检测的蛋白质。要知道很多药物如果用药过量后果就会很严重,比方说抗血栓药物,而多数药物都是小分子药物,分子本身最多包含50个原子。最近我们就成功设计了一些可以紧密结合小分子的蛋白质。一旦用药过量,这些蛋白质也许可以当做解药。比方说,我们最近设计了一个蛋白质,可以用于心脏病药物地高辛的过量解毒。我们正在与其他的实验室合作,用这些蛋白质来检测血液样本或环境中的小分子药物。
Message 75630 - Posted 20 May 2013 6:00:18 UTC | We have discovered how to make several new classes of protein structures! Rosetta@home has been absolutely critical in this work: when we design a sequence to fold into a new structure, the last thing we do before ordering a synthetic gene so we can make the protein in the laboratory is to send it out to you to predict the structure-if it folds to the structure we designed, we go ahead with it, but if you find that the lowest energy state is a different structure we go back to the drawing board. Our success rate in making brand new structures is far higher than I or anybody else ever expected, and the reason the success rate is so high is that your calculations provide a very stringent test of whether the designed sequence will actually fold the way it is supposed to. In the next few weeks I and other scientists here will describe to you the new classes of proteins we are making, and the many applications they will be useful for. Thank you for your absolutely essential contributions to this newly emerging scientific field!
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2013年5月20日
参见http://www.equn.com/forum/forum. ... d=501655&ptid=25064
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