|
|
本帖最后由 金鹏 于 2012-4-5 08:24 编辑
April 03, 2012
Receptor Binding by the Influenza Virus
The Kasson group has recently published an article in the journal Biochemistry on how influenza binds cell-surface receptors. In this article, we discuss how computational techniques can be used for further analysis of structural and biochemical data on glycan binding by influenza. We review prior work that we have done in collaboration with the Pande group, including research using Folding@home. Those earlier papers can be found here and here.
The table-of-contents graphic from our recent paper shows how dynamics the glycan (sugar) residues on the surface of the influenza hemagglutinin protein can be. 20 structures of the glycan molecules are superimposed on the receptor-binding pocket of hemagglutinin.
大意：
Kasson小组在生物化学杂志上发表了，有关流感病毒如何与细胞表面受体结合的文章。文章阐述了计算技术（FAH）在研究中起到的作用。
vmzy 发表于 2012-4-4 09:55 
http://pubs.acs.org/doi/abs/10.1021/bi201684v
http://pubs.acs.org/doi/abs/10.1021/ja904557w
http://www.cell.com/biophysj/abstract/S0006-3495(08)78452-2 |
|
发表于 2012-4-5 08:22:02
发表于 2012-4-5 09:16:38
