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1/14/2005 Folding@Home breaks 170,000 active CPUs. Folding@Home continues to attract more donors. Thanks to all for their contributions! The great outpouring of support has really paid off, allowing us to perform calculations which would otherwise be impossible (even with exclusive use of high end supercomputers like IBM Blue Gene). For example, we'll be making an announcement of some recent results related to cancer soon.
2005年1月14日
Folding@Home突破170,000个活跃CPU。Folding@Home继续吸引更多的志愿者。感谢他们的所有贡献！由于你们的大力支持，允许我们进行计算，没有你们计算是不可能(甚至用象IBM的“深蓝”一样的最高端的专用巨型计算机)的。例如，不久我们将做一个与癌症有关的一些近期结果的通告。
1/15/2005 First results from Folding@Home cancer project published. We have been studying the p53 tumor surpressor and our first results have recently been published . To our knowledge, this is the first peer-reviewed results from a distributed computing project related to cancer. Thanks to the continued support of FAH donors, this is will be just the first of many cancer related works that will come from FAH.
The nature of our results can best be described in our paper. However, here's a brief summary of our results. Roughly half of all known cancers result from mutations in p53. Our first work in the cancer area examines the tetramerization domain of p53. We predict how p53 folds and in doing so, we can predict which amino acid mutations would be relevant. When compared with experiments, our predictions have appeared to agree with experiment and give a new interpretation to existing data.
2005年1月15日
首个Folding@Home癌症项目的结果公布。我们一直研究p53 surpressor瘤，我们的第一个结果最近已经出版了。据我们所知，这是第一个来自有关癌症的分布计算项目的同行评议结果。感谢FAH志愿者的不断努力和贡献，这只是FAH众多与癌症相关工作的开端。
在我们的文章里详细地描述了我们的结果的性质。不过，这只是我们的结果的概要。大约只有一半的p53的所有癌变结果。我们的第一个在癌症领域的工作是检查p53的四聚物功能。我们预测p53怎样折叠。这样，我们就能预测哪个氨基酸的变化将是与癌变有关的。与实验相比较，我们的预测看起来已经与实验相符，并且给了现有的数据一种新的解释。
翻译 BY VMZY |
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发表于 2005-1-17 22:20:41
发表于 2005-1-17 23:33:02
