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本帖最后由 金鹏 于 2010-6-26 12:07 编辑
Thu Jun 24, 2010 9:43 pm
publication of FAH results on membrane fusion and influenza
We are happy to announce the publication of some of our FAH scientific results:
"Atomic-Resolution Simulations Predict a Transition State for Vesicle Fusion Defined by Contact of a Few Lipid Tails"
This paper describes work on the mechanism of vesicle fusion, a process involved in viral infection, the transmission of nerve impulses, and cellular secretion.
FAH project 2681 directly contributed to this work; we are also following up several other avenues.
http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000829
A summary follows below:
Membrane fusion is a common underlying process critical to neurotransmitter release, cellular trafficking, and infection by many viruses. Proteins have been identified that catalyze fusion, and mutations to these proteins have yielded important information on how fusion occurs. However, the precise mechanism by which membrane fusion begins is the subject of active investigation. We have used atomic-resolution simulations to model the process of vesicle fusion and to identify a transition state for the formation of an initial fusion stalk. Doing so required substantial technical advances in combining high-performance simulation and distributed computing to analyze the transition state of a complex reaction in a large system. The transition state we identify in our simulations involves specific structural changes by a few lipid molecules. We also simulate fusion peptides from influenza hemagglutinin and show that they promote the same structural changes as are required for fusion in our model. We therefore hypothesize that these changes to individual lipid molecules may explain a portion of the catalytic activity of fusion proteins such as influenza hemagglutinin.
大意：
公布膜融合与流感的研究结果
June 25, 2010
Update on the v7 client
Here's an update on our v7 client efforts. The v7 client is a complete re-write in order to make the client more reliable, simple to maintain, and easier to include features that donors have requested. The first versions will not have everything that donors have asked for, but there will be some significant changes, such as the integration of classic, SMP, and GPU clients, the ability for a single client to handle all of these (eg multi-core + GPU) simultaneously (via multiple cores), a cleaner and more reliable GUI, much better and sophisticated tools for 3rd party developers, and in time the ability to use the FAH client to manage multiple machines easily.
The console version of the v7 client has gone through internal testing and we're starting a very limited alpha release. There are definitely some rough edges, but I'm excited to see it get this far. Assuming there are no show stoppers, I hope that we'll have something ready for open beta testing in a month or two, maybe sooner.
大意：
v7客户端消息
v7客户端包括的新功能有：单核、smp、gpu客户端合体（通过兼容不同的core实现），更稳定的图形界面，第三方程序接口，方便的对多个客户端进行管理。
命令行版已经通过内测了。如果一切顺利的话，将于1、2个月内开始公测。
PS:怎么没有提到BIGADV客户端呢？还是单干？ |
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发表于 2010-6-26 12:02:56
发表于 2010-6-26 17:17:53
