本帖最后由 xhl1212 于 2020-7-9 00:37 编辑
We are actually expanding a lot of human genes, prioritizing them according to the scientists' interests. Among them this one (ACE2) https://www.ncbi.nlm.nih.gov/gene/59272
which is closely related to the SARS-CoV-2 virus. Don't expect we will be able to 'find a cure' but we are trying to add something to better know our enemy.
In the mean time, please, take care.
- 发表于：19 Mar 2020, 23:08:59 UTC
We just added some other genes related to ACE2, according to this https://string-db.org/cgi/network.pl?taskId=fBQjTFzroyIX
They are AGT AGTR1 AGTR2 REN MME DPP4 PRCP MEP1B MEP1A XPNPEP2, among them we already expanded MME and DPP4. You may see the others' names coded inside the workunits string.
- 发表于：28 Mar 2020, 23:01:43 UTC
最近的修改日期：28 Mar 2020, 23:02:11 UTC
Added a few genes, related to DPP4, according to StringDB:
INS GIP SLC5A2 SLC5A5 ADA GCG GLP1R
- 发表于：3 Apr 2020, 16:00:13 UTC - 回复消息 1740
最近的修改日期：3 Apr 2020, 19:55:46 UTC
We already published the OneGenE (expansion of all the genes) results for a Vitis vinifera dataset (Vespucci).
The OneGeneE project for Homo sapiens FANTOM-5 gene expression dataset is our 'background' job, and it is a very long one. We normally put genes in the queue in alphabetic order (actually it is by 'number of isoforms', but it would be the same). At the very beginning we started by prioritizing genes related to neurovegetative diseases, then to some types of cancer, right now any gene possibly related to COVID-19 (you guess why...).
Any result we get is immediately available to the scientific community (biologists etc.), for example the ACE2 expansions we completed a few days ago will soon be analyzed by a immunologist, etc.
We are also studying the possibility of doing some work on specific gene datasets recently made up from cells of SARS-CoV-2 infected individuals. In this case we will put 'on hold' the OneGenE Hs project.
Already received work from other batches ahead of 166977.
Are these still SARS-CoV-2 related or from the Homo Sapiens (OneGenE - FANTOM-1) data set?
mixed, for now, for instance ENPEP and TMPRSS2 should be related to SARS-CoV-2. Keep in mind that all genes/isoforms are taken from the FANTOM dataset. We are prioritizing those (human) genes related to the Covid-19 disease, infection and/or pathology.
The first batch of genes related to COVID-19 has been completed. We sent the results, for further analysis, to the Univ. of Modena & Reggio Emilia School of Medicine, Italy. Starting from today we added another batch of genes, per request of the aforementioned institution. Most of them are antibodies, so the focus right now is the immune system.
Here is the list of the genes: PTPRC CD28 CCR7 PDCD1 SNCA SPATA2 CD27 B3GAT1 IL7 IL2RA ISG20 FAS PTPN13 CD38 CD74 CD24 CR2