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400 compounds from the second phase of the project (LigandFit) have been synthesized and tested in a lab. Between 2-4% of them show activity. Typically less than 0.1% of compounds from computer-simulated screening show activity. The next step for the successful compounds "is to persuade pharmaceutical or biotechnology companies to take up these experimentally verified hits and to test them further."
译文如下:
来自第二阶段项目(LigandFit)的400种化合物已经被合成,并在一个实验室测试。他们之间有2- 4%表现活性。通常来自计算机模拟筛选的化合物不到0.1%表现活性。 对那些成功化合物而言,下一步"是说服医药或者生物制药公司从实验上证实这些命中,并更进一步测试他们" 。 |
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