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[BOINC] [生命科学类] Rosetta@home

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发表于 2018-3-30 18:54:24 | 显示全部楼层
2018-03-28: Rosetta@Home, Science opinion article about protein engineering and David Baker

Checkout a recent Bloomberg science opinion article about some of the science behind this project, protein engineering, and David Baker, titled Protein Engineering May Be the Future of Science.







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2018-03-28: Rosetta@Home, 科学评论文章:蛋白质工程与David Baker
美国彭博公司(Bloomberg )近日发表了一篇题为《蛋白质工程有望成为科学的未来发展方向(Protein Engineering May Be the Future of Science)》的科学评论文章,介绍了Rosetta@home 项目背后的一些科学知识、蛋白质工程,以及David Baker 。

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发表于 2018-9-18 22:50:04 | 显示全部楼层
2018-09-17: Rosetta@Home, Fluorescent proteins designed from scratch

Congrats to all Rosetta@home volunteers who contributed to a recent report in Nature describing the design of a completely artificial fluorescent beta-barrel protein. As described by one of the main authors, Anastassia, in this forum post:

The paper presents many ?firsts? in computational protein design. It is the first de novo design of the beta-barrel fold (one of the most described folds in the past 35 years, yet mysterious until now). It is also the first de novo design of a protein tailored to bind a small-molecule, which requires very high accuracy in the placement of side chains on protein backbones assembled from scratch. Additionally, we could show that these new proteins could fold and function as expected in vivo! We hope that the advances described in the paper will further enable the de novo design of many biosensors and catalysts tailored for specific applications.

Thanks to all the Rosetta@home volunteers who contributed to the validation of our designed proteins and binding sites.

Here is the link to the IPD webpage that contains a copy of the paper. The work was also featured in the news articles below (the news in Science contains a video of one of our proteins glowing in living cells).

https://www.bakerlab.org/index.php/2018/09/12/de-novo-fluorescent-proteins

https://cen.acs.org/physical-chemistry/periodic-table/Designer-protein-tackles-binding/96/i37
http://www.sciencemag.org/news/2018/09/watch-these-new-designer-proteins-light-when-they-hit-their-target








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2018-09-17: Rosetta@Home,一种完全人造的荧光蛋白
近期发表在《自然》杂志上的一篇论文表明,研究团队成功的设计出了一种自然界中不存在的荧光蛋白。恭喜各位Rosetta@home的志愿者,你们在这项研究中做出了巨大的贡献。论文的主要作者之一Anastassia 在帖子中说道:
我们的论文在计算机蛋白质设计(computational protein design)领域中提出了几个“第一”:第一次从头设计出β桶形结构(beta-barrel fold)折叠(这种折叠方式是在过去35年中被提及最多的折叠方式,但其机理至今尚未被解明),以及第一个从头设计的剪裁后能与特定小分子结合的蛋白质。这项技术需要在给蛋白质的主链安装侧链的时候达到相当高的精度。另外,我们还能够证明这些全新的蛋白质能够如预期的方式在(生物)体内折叠并发挥功能!我们希望论文中的进一步论述能够推进从头设计生物传感器,以及为特定应用定制触媒等工作的进展。
感谢Rosetta@home项目的各位志愿者,你们在对蛋白质设计方案及结合位点的验证工作上做出了卓越贡献。
这里是IPD页面,上面有一份论文的副本:https://cen.acs.org/physical-che ... kles-binding/96/i37
另外,《自然》杂志还对本研究发表了一篇新闻特写(报道中还提供了一段论文中设计的蛋白质在活细胞中发光的视频片段),链接在此:http://www.sciencemag.org/news/2 ... ey-hit-their-target



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